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39 ASCT1 and ASCT2, which have mainly been studied in the context of glutamine dependence, are expressed at high levels in different cancer types, 40,41,42 prompting these transporters to be considered putative therapeutic targets in cancer, with different inhibitors currently under investigation

Conclusion In summary, several studies have suggested that the gut microbiota and its metabolites play vital roles in the development of RE through the regulation of inflammatory signaling, which affects ISCs and immune cells