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The potential molecular mechanisms underlying these effects included disturbances in redox homeostasis (as evidence by the enhanced production of ROS and reactive nitrogen species), failure of enzymatic and nonenzymatic cytoprotective mechanisms involving the glutathione system as well as nuclear factor kappa B (NF-B) and fibroblast growth factor 2-mediated pathways, and impaired mitochondrial function

10.1016/j.heliyon.2022.e08878 65 MontalbettiN.SimoninA.KovacsG.HedigerM

However, antacids should not be used as a long-term solution

Crit Rev Biochem 23:283337

Still, pharmaceutical companies are racing to investigate new, improved relatives of semaglutide