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At the phylum level, Verrucomicrobia was increased, and at the genus level, Anaerotruncus , Akkermansia , Bifidobacterium , Coprobacillus , Intestimonas , and Clostridium_XVIII were increased, and Coprobacter was decreased in temozolomide treated mice when compared to the vehicle-treated mice

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Even though experimental and observational studies show a significant correlation between elevated levels of plasma TMAO and adverse cardiovascular events, the precise mechanism is still in place and unidentified [11]