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Retrospective case series of paediatric patients referred to national poisons centres also report a lower rate of liver injury and hepatotoxicity in children compared with adults following single acute overdose [52,53,54,55]

The decrease of fat cell size and mass in supplemented obese rats was due to the increase energy metabolism through browning of WAT, the increase of expression of UCP1, and down-regulation expression of key adipogenic marker proteins (PPAR, C/EBP, CD36, aP-2, and perilipin (Kundimi et al., 2020)

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