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In the SEPRA pragmatic trial, fewer semaglutide users added a new glucose-lowering treatment at 1 year [30]

In another study, FTH1 and FTL mRNA overexpression and FTH1 protein overexpression measured by immunoblot were shown in AML primary cells compared to peripheral mononuclear cells ( in vitro cytotoxic activity of cytarabine was detected in FTH1 overexpressing AML

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Both approaches target the same GLP-1 receptor pathways involved in appetite regulation, blood sugar control, and gastric emptying