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Currently, fewer than 20% of IBS-C and less than 10% of IBS-D patients report ever having been treated with FDA-approved medications 9

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Methods This retrospective cohort study utilized the TriNetX electronic health record database, a multinational and multi-institutional database

Nonsurgical therapies include off-label topical imiquimod and radiation therapy, which are generally second-line but may be preferable in certain instances based on patient comorbidities and/or limited life expectancy, quality of life issues, and/or preference for nonsurgical treatment