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GLP-1R activation by endogenous ligands or pharmacological agonists stimulates adenylate cyclase (AC) through Gs coupling, leading to elevations in intracellular cAMP and enhanced insulin secretion from pancreatic -cells (2)

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The possible mechanisms may involve effects on GLP-1 hormones, the authors of the trial hypothesize, "that are secreted from the gastrointestinal tract and affect appetite by regulating digestive processes and neural signaling in the central nervous system." Medicinal plants are also turning out to be fruitful areas of research