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This in turn induces expression of nuclear kappa B expression that activates TLR-4 and proinflammatory cytokines such as TNF- and IL-6 and IL-8 (Figure 3) (110, 111)

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Neurotransmitter synthesis : B6 is essential for producing serotonin, dopamine, and GABA, all of which regulate mood and cognition

Key measurements include lipid peroxidation markers such as malondialdehyde and 4-hydroxynonenal, antioxidant defense markers such as GPX4 activity and the GSH/oxidized GSH ratio and advanced MRI-based assessments such as quantitative susceptibility mapping to quantify brain iron deposition (95,96)

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