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(1) Dapagliflozin when used as a component of XIGDUO XR, is indicated in adults with type 2 diabetes mellitus to reduce the risk of: Sustained eGFR decline, end-stage kidney disease, cardiovascular death, and hospitalization for heart failure in patients with chronic kidney disease at risk of progression

Wang E, Patorno E, Khosrow-Khavar F, Crystal S, Dave CV

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The increase in mEPSC frequency observed in GLP-1 R-Cre::tdTom::Lep ob/ob mice appeared to be due to a 41% decrease in inter-event intervals in leptin-deficient mice (Figure 6I