Koeth RA et al
Comparison of the effects of glucagon-like peptide-1-(1-37) and -(7-37) and glucagon on islet hormone release from isolated perfused canine and rat pancreases
GLP1R expression differences between females and males Our finding of a consistent sex difference in the adverse effects of GLP1R agonists (after adjusting for differences in weight loss efficacy) across three species raises the possibility of inherent, sex-dependent differences in responsiveness of GLP1R-expressing neurocircuitry
The researchers concluded that MOTS-c may serve as a promising therapeutic target for inflammatory pain.23 Bone growth MOTS-c promotes osteoblast proliferation, differentiation, and mineralization, say the authors of a 2023 review.24 Osteoblasts, by the way, are cells that both form new bones and heal existing ones the more of them you have, the stronger and denser your bones are likely to be.25 So MOTS-cs osteoblast-promoting action is great news for anyone at high risk of developing osteoporosis, such as postmenopausal women.26 Quality of life Each of the health concerns weve addressed here metabolic dysfunction,27 increased body fat,28 decreased physical capacity,29 increased inflammation,30 and reduced bone density31 often correlates with advanced age, so it follows that attenuating these factors would result in a more robust and enjoyable aging experience
10.1016/j.regpep.2005.05.001 10 BloemenJ
