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The mechanism behind oral efficacy is attributed to systemic absorption and downstream peptide signaling rather than localized delivery, though the exact bioavailability percentage in humans remains unquantified

SVR, systemic vascular resistance

TL;DR Zepbound (tirzepatide) is an FDA-approved injectable medication that works by activating two hormone receptors-GLP-1 and GIP-simultaneously, making it the first dual-agonist weight loss drug

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