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GHRP-6 takes the opposite approach

Acromegaloid features, including jaw growth, soft-tissue swelling, and peripheral nerve entrapment, are described after sustained supraphysiologic exposure [1]

These IGF-1 axis studies have established Ipamorelin as the reference GHS-R1a agonist for studying GH-driven IGF-1 biology in research protocols where prolactins independent IGF-1-stimulating biology in liver and peripheral tissues would otherwise confound interpretation

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A promising therapeutic approach being studied uses IGF-1 analogues such as PEG-IGF-1 [263], which offers promising protection against acute contraction-induced muscle injury