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There is insufficient evidence to recommend allulose as a therapeutic intervention for glycemic control, and it should not replace prescribed medications or established dietary management strategies

For instance, methotrexate, the cornerstone DMARD, provides clinical benefit in just 30 - 40% of patients and is associated with hepatic toxicity in 10 - 0% (8)

This gradual escalation minimizes gastrointestinal adverse effects such as nausea, vomiting, and diarrhea, which are the most common reasons for treatment discontinuation

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10.1016/j.foodchem.2007.12.084 43 GongY