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Direct interaction studies are limited, but ashwagandha is known to improve insulin sensitivity in type 2 diabetes trials, and GLP-1 medications also lower blood glucose

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They have recently published a paper to this effect in the journal ACS Chemical Neuroscience

Elite J Med Sci 2(4):7687 Ou YN, Kuo K, Yang L, Zhang YR, Huang SY, Chen SD, Deng YT, Guo Y, Zhang RQ, Wu BS, Tan L (2024) Longitudinal associations of cardiovascular health and vascular events with incident dementia

The Canadian market currently offers several approved medications, with Retatrutide representing what may become available in the near future