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Phase IIb Results and Regulatory Status A larger Phase IIb trial involving over 500 overweight and obese subjects was conducted to further evaluate efficacy and safety

however, this was not recapitulated by genetically eliminating Dpp4 as Picrosirius red staining revealed a trend toward increased fibrosis, and expression of Col1a1 and Col3a1 was increased in Dpp4 / mice

PMID: 74 KhoiC

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By understanding why patients reach a treatment plateau and how to manage it effectively, clinicians can help preserve long-term progress, improve patient confidence, and support better outcomes in both diabetes and obesity care