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Aging is associated with functional and phenotypic alterations in the microcirculation, including endothelial dysfunction, oxidative stress, chronic low-grade inflammation, and microvascular rarefaction (reduced number and combined length of small vessels in a given volume of tissue)[289]

Husain, M

Pigmentacin Racial En las personas de raza negra o tez morena es posible encontrar a nivel gingival, por vestibular, especialmente en encia de los incisivos superiores e inferiores, tambin en caras internas de mejillas, zonas cafe oscuras, con aspecto simtrico y que son las zonas pigmentadas ms frecuentes de la mucosa

Gastrointestinal symptoms: Some peptides, especially GLP-1 receptor agonists such as semaglutide or tirzepatide, can slow digestion, which may lead to nausea, vomiting, diarrhea, or constipation