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Providers may advise patients to: Choose the same day and time each week for their injection Inject Mounjaro with or without food Ensure at least 72 hours between doses if the injection day is changed Be prepared for Mounjaro dosing escalation , beginning with 2.5 mg once weekly and increasing gradually to reduce gastrointestinal effects Pairing the injection with a weekly habitsuch as a specific meal or remindercan improve adherence and ultimately lead to better outcomes in blood sugar management and weight loss