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Exclusion criteria for all groups included current or previous psychiatric comorbidities as diagnosed by DSM-5, using a structured interview (The Structured Clinical Interview for DSM-5, SCID-5) [28] if deemed relevant by the investigator, any general medical conditions known to influence energy processing and/or linked to fatigue, current treatment with any medication/supplementation likely to interfere with energy metabolism if deemed relevant by the investigator, contra-indications to magnetic resonance (MR) imaging, pregnancy or breast feeding

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The peptide occurs naturally in the human body, and copper toxicity is uncommon with properly dosed applications

The use of Semaglutide is showing great promise in those struggling with weight loss and long term healthy weight management

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