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It took some rulemaking, patience, humor, and an occasional blind eye

While these medications are generally well tolerated, gastrointestinal side effects such as nausea and constipation are common and have been reported to limit therapy [2, 3, 4]

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Our proposition is that the suboptimal glutathione levels associated with so many chronic diseases are not due to a cysteine undersupply but an impairment in one of the multiple control mechanisms of the GCL enzyme