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Previous studies have shown that when cortisol levels become extremely high and the brain is unable to control the excessive production of cortisol, a decrease in the concentration of brain-derived neurotrophic factor (BDNF) is detected, which affects the development of depression through tyrosine kinase receptor (TrkB) and p75 neurotrophic factor receptor (p75NTR) (30, 31)

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Unlike other antioxidants that work in specific tissues or target particular free radicals, glutathione functions as a comprehensive cellular protection system