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Originally developed to help treat type 2 diabetes, GLP-1 drugs have proven effective at promoting weight loss , at least for as long as the medications remain in use

The neuroprotective effect in this study was through activation of the SIRT1/PGC-1 pathway

Zeng F, Lai M, Li Q, Zhang H, Chen Z, Gong S, Liu X, Liu B (2023) Anti-oxidative and anti-aging effects of mannoprotein-rich yeast cell wall enzymatic hydrolysate by modulating gut microbiota and metabolites in Caenorhabditis elegans

For others, its a genetic DAO deficiency that becomes clinically relevant only when exacerbated by the wrong medication

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