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Morphological characteristics of necrosis such as organelle swelling, release of cell components and karyolysis are evident in hepatocytes after APAP injury (Jaeschke et al., 2004)

LOXs catalyze the oxidative deamination of lysine and hydroxylysine side chains of collagen and elastin precursors to produce highly reactive semialdehydes called allysines

Treatment of cells with a peptide containing only the HIV-TAT sequence, as well as a peptide where the HIV-TAT sequence was introduced into the N-terminus of p53 TAD PEP, resulted in a minimal induction of cell death (Figure