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Compared with diet-induced obese models (23, 36, 37), Bbs5 / mice exhibited distinct metabolic and immune characteristics, including rapid weight gain, pronounced immune dysregulation, and accelerated deterioration of glucose homeostasis and pancreatic function

In supportive logistic regression analysis, semaglutide was associated with substantially higher odds of achieving 10% weight loss at 6 months (OR 14.84

The LOQ for L-and D-carnitine was determined at 2 mg/g (S/N 10)

These effects typically occur during dose escalation and are generally mild to moderate in severity

These minor gene effects could be detected by studying a much larger sample size