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The SURMOUNT-1 Phase 3 trial published in the New England Journal of Medicine demonstrated 20.9% mean body weight reduction at 72 weeks on tirzepatide 15mg weekly versus 3.1% with placebo

GLP-1 receptor activation mimics satiety signals sent to the brain, specifically the hypothalamus, which regulates appetite and food intake

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For this experiment, six - 46-month-old healthy male New Zealand white rabbits (average weight: 22.5 kg) were housed at the National Research Centre animal house

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