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From experimental data of kinetic measurements of BRET, following vehicle and baseline corrections, quantification of induced responses from individual peptide concentrations was determined by calculating the net area under curve from the 10 min response (AUC 0-10min) ) in GraphPad Prism version 9.0.1 (GraphPad Software Inc., San Diego, CA)

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Cellular uptake of ANG-LP-PAA-MSN@FITC was 2.16-fold higher in C6 glioma cells and 2.56-fold higher in brain endothelial cells compared to non-targeted LP-PAA-MSN@FITC