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Kidney-related complications, including nephrolithiasis and interstitial nephritis, have been reported in comprehensive safety analyses ^36

A single overnight exposure at 15C can reduce bioavailability by 1520%, while exposure above 30C for even two hours can denature the peptide structure entirely, rendering it biologically inactive regardless of subsequent refrigeration

The gut microbiota-produced vitamin B6 mitigates alcohol-associated liver disease by attenuating hepatic oxidative stress damage