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Who This Approach Applies To and Important Safety Considerations This timing optimization framework applies to individuals already prescribed compounded semaglutide by a licensed healthcare provider

DPP4 inhibitors, which work within the physiological range to enhance GLP-1 activity, may have additional pleiotropic effects beyond their GLP-1 activities (Figure 3)

Semaglutide was removed from the FDA's drug shortage list in February 2025, and tirzepatide followed in December 2024

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