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The diagnosis of melanoma is straightforward if the histologic appearance is that of an obvious malignant tumor (necrosis, atypia, mitoses, infiltrative growth), but it can be difficult when mitoses are rare and the degree of atypia is low

In addition to the rationale related to evolution of these organelles, compelling arguments for the association of melatonin with mitochondria come from the elegant work of Suofu and colleagues (93) and a publication by He et al

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