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Curiously, dopamine-producing neurons outside of the SN tend not to be affected, though many other neuronal types glutamatergic, cholinergic, tryptaminergic, GABAergic, noradrenergic, adrenergic show grievous cytoskeletal damage, according to Braak and Braak

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In a recently completed phase 2 trial (abstract data), 46 weeks of survodutide once weekly (0.6 to 4.8 mg) resulted in a dose-dependent mean WL up to 18.7% vs

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