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In addition to haemodynamic overload, uraemic toxin accumulation and altered ion homeostasis, which are known to underlie left ventricular hypertrophy in CKD and drive cardiac dysfunction, we examine the role of myocardial metabolic remodelling in CKD

Softer or liquid protein sources may be easier to consume when appetite is suppressed

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For a fuller treatment of these metabolic-health outcomes, see the key findings on retatrutide for managing obesity and metabolic health

Patients should contact a healthcare provider if side effects are severe, persistent, worsening, or interfering with eating, drinking, or daily functioning