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doi: 10.3389/fendo.2026.1825853 Received 08 March 2026 Revised 08 April 2026 Accepted 09 April 2026 Published 28 April 2026 Volume 17 - 2026 Edited by Spyridon N

& Bohlin, T

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This approach challenges more traditional road safety strategies where some degree of death and injury is seen as an acceptable price to pay for the benefit of car-based mobility

Research scenario Better conceptual fit Reason Testing GLP-1 plus satiety-pathway extension CagriSema Combines semaglutide with amylin analog activity Testing maximum receptor breadth Retatrutide Activates GIP, GLP-1, and glucagon receptors Studying diabetes plus obesity together Both Both have programs relevant to T2D and weight Comparing incremental vs radical next-gen strategy Both CagriSema extends GLP-1