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If someone is struggling with persistent nausea or diarrhea at their current dose, the provider can hold or even temporarily reduce the dose rather than pushing forward

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Additionally, COMT , the methyltransferase responsible for inactivating catechol estrogen through DNA methylation, exhibits promoter hypermethylation in ectopic endometriotic samples, possibly reflecting an alteration of estrogen metabolism functions [85]

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La vida media biolgica del GLP-1 in vivo es corta (aproximadamente 2 minutos) y se degrada rpidamente por la accin de la enzima dipeptidil dipeptidasa-4 (DPP-4) 21 , por tanto, el enfoque farmacolgico ha sido dirigido a prolongar la vida media del GLP-1, ya sea por modificacin estructural del pptido original o por inhibicin de la enzima DDP-4