Therefore, in the present study, cultured microglia were exposed to OGD/R to mimic ischemia/reperfusion injury in vitro and were used to determine whether Sirt1 could regulate microglial activation and inflammation following OGD/R injury in vitro and whether these effects were mediated via Shh/GLI family zinc finger-1 (Gli-1) signaling
But ROS also play useful roles in the body, including helping regulate cell signaling and, in some cases, contributing to cancer cell death.37 38 That means antioxidants can cut both ways
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