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Missiroli S, Genovese I, Perrone M, Vezzani B, Vitto VAM, Giorgi C

A 1:1 propensity matching was also employed to account for confounders, including demographics, comorbidities, insulin use, and use of other second-line diabetic agents

Given that MTX is more effective against dividing cells because of its effect on the nucleotide synthesis, we also examined correlations between metabolites concentrations and cell proliferation rate, as this could be a confounding factor (proliferation curves for doubling time determination are in Supplemental Figure 5 )

Study raises red flags over long-term effectiveness of popular weight loss drugs like Ozempic Ozempic, Mounjaro, and Zepbound can help people lose weight fast, but once the drugs stop, the weight often comes rushing back

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