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doi: 10.1111/dom.70141

This third mechanism introduces direct hepatic fat mobilization, increased thermogenesis through brown adipose tissue activation, and accelerated peripheral lipid oxidation

Colonic absorption of unconjugated bile acids: Perfusion studies in man

Pipeline drugs like Vikings VK2735 and Amgens AMG 133 could raise the bar further by innovating on both biology and delivery, such as new receptor targeting strategies, novel molecular designs, and more patient-friendly dosing schedules