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Greater Weight Loss Was Linked to Lower Risk Compared with patients whose BMI fell by 0% to less than 5%, those who reduced their BMI by at least 15% had a 37% lower risk of osteoarthritis, a 30% lower risk of CKD, a 69% lower risk of OSA, and a 32% lower risk of heart failure

Bate A, Evans SJW

One study divided 93 patients aged 50+ with confirmed knee OA into 3 groups: one group was treated with conventional physical therapy, another with exercise therapy, and a third with high-intensity laser therapy

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Lower 5-HT4 receptors and greater occupancy by escitalopram was correlated with poorer verbal affective memory, but not depressive symptoms, suggesting that 5-HT4A receptors could represent a promising therapeutic target for cognitive deficits [117]