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(June 2002)

Reactive astrocytes as therapeutic targets for brain degenerative diseases: Roles played by metabotropic glutamate receptors

doi: 10.1111/j.1753-4887.1958.tb00725.x 129 Ochoa-VialsN.Alonso-EstradaD.Pacios-MichelenaS.Garca-CruzA.Ramos-GonzlezR.Faife-PrezE.et al

In addition, bile acids activate the GPCR of PP cells, and Takeda G-protein receptor 5 (TGR5) stimulates PYY release, whereas H 2 S produced by sulfate-reducing commensal bacteria in the colon inhibits TGR5-dependent PYY release involving the PLC-/calcium ion pathway ( Therefore, while it appears that PYY possesses formidable weight-reducing properties, exogenous PYY negatively regulates bone mass and strength in adults and has long-term deleterious side effects on bone, including increasing the risk of fracture, so care should be taken in treating obesity with PYY