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Evidence Strength Rating Moderate plausibility via reduced intake Limited direct clinical outcome data 4.2 Vitamin B12 Physiological Role Vitamin B12 supports: Neurological function Red blood cell production DNA synthesis It is primarily obtained from: Meat Dairy Fish Why GLP-1 Therapy May Influence B12 Possible mechanisms: Reduced intake of animal products Chronic low-calorie intake Gastric acid modulation secondary to delayed gastric emptying (theoretical) Unlike metformin, GLP-1 drugs are not known to directly impair B12 absorption

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In 2017, a single-center, randomized, double-blind clinical trial was conducted to evaluate the efficacy of 2 mg once-weekly of exenatide compared with placebo in patients with PD

Ideally, electrolytes come from food