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Studies show structured exercise and protein preserve 8590% of lean mass during GLP-1 therapy, so muscle loss is largely preventable through intentional choices rather than inevitable

Efficacy depends on proper dose titration and adherence

Naltrexone blocks the opioid receptors those endorphins act on, so the buzz is muted

ZhaoDZhangQLiuYLiXZhaoKDingYet al

Other potential risk factors Several other potential risk-modifying factors were explored but were removed from adjusted analyses due to not being independently significant as covariates and not contributing significantly to the information criterion