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ACKNOWLEDGMENTS We thank the Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq, proc

No other potential competing interests relevant to this article are reported

Compared with the results of prototype BPC157 in rats, the pharmacokinetic parameters of [ 3 H]BPC157 evaluated based on total radioactivity changed markedly, indicating the significant metabolism and decomposition process of BPC157 in vivo

This modification resulted in enhanced ALP-activity, mineralization, and osteogenic marker expression ( ALP , COL1A1 , RUNX2 ) via autocrine signaling