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The Maintenance Trap: Why Most People Regain Post-GLP-1 Weight regain is generally expected when people discontinue taking GLP-1s

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Synthetic GLP-1s, on the other hand, have been modified to make the molecular agonists more resistant to breaking down and have a half-life of nearly seven days when injected, the filing says

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This weight reduction occurs through multiple mechanisms, including reduced appetite, increased satiety, and the delayed gastric emptying mentioned above