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IGF-I and IGFBP-2 stimulate AMPK activation and autophagy, which are required for osteoblast differentiation

However, under oxidative stress conditions, Nrf2 dissociates from Keap1 and translocates to the nucleus, where it activates various antioxidant genes, including HO-1, protecting cells from oxidative damage

Ramping Up: Doctors will start you on a low dose to let your body adjust and minimise nausea, then slowly increase the dosage over several months

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