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A collaborative study

Chatterji A, Holmgren A, Sengupta R (2021) Ribonucleotide reductase: In-vitro S-glutathionylation of R2 and p53R2 subunits of mammalian class I ribonucleotide reductase protein

TB-4 (full-length, 43 aa) moves repair cells into position and biases healing toward functional tissue rather than rope-like scarring

Cellular susceptibility to ferroptosis is therefore governed by pathways controlling lipid metabolism, iron homeostasis, and redox balance

A follow-up cohort study further demonstrated that this association is partly mediated by low-grade systemic inflammation, highlighting inflammation as a mechanistic link between chronic NSW and IBS risk 155