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Beyond our demonstration of the effects of GLP-1(2836) on IRI and a role for sAC in its biology, there is a small emerging body of evidence supporting a role for GLP-1(2836) in preventing obesity, insulin resistance, diabetes mellitus, and hepatic steatosis and gluconeogenesis in mice (11, 24, 27, 41, 42)

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This variability may be attributed to the release of miR-122 from healthy liver cells, which can have physiological effects on distant tissues [71]