Recently, mesoporous silica nanospheres (MSNs) as nano-carriers attracted much attention due to chemically modifiable surfaces, high surface area, characteristic nanostructure, biocompatibility and a large load capacity 32,33,34
However, drug resistance limits its efficacy, illustrating the importance of overcoming tamoxifen resistance in breast cancer
Distinct effects of inflammation on cytochrome P450 regulation and drug metabolism: Lessons from experimental models and a potential role for pharmacogenetics
The SLC38A3 (SNAT3) gene is known to be overexpressed in cases of triple-negative BC and has been shown to promote cancer cell invasion and metastasis through the SLC38A3/GLULK3/-linker protein/EMT pathway [63]
Moreover, histone lysine-specific demethylase 1 (LSD1) of the JmjC and JmjD families require -KG as a cofactor for the demethylation process (156), whereas succinate and fumarate inhibit its demethylation process (160)