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It occurs naturally in human plasma, saliva, and urine, and its plasma concentration declines significantly with age, from approximately 200 ng/mL in young adults to much lower levels in older individuals

Everything else comes from animal models

The DSIP, or the Delta sleep-including Peptide, is a somnogenic nonapeptide that easily bypasses the blood barrier to impact neuromodulation

However, researchers acknowledge they are far from developing a clinical application

This is especially important for people who are taking other supplements or medications, and people with pre-existing conditions, such as kidney disease