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Some clinicians and researchers explore split semaglutide dosing twice weekly or split tirzepatide dosing as a way to maintain more consistent blood levels and potentially improve results while reducing peak-dose side effects

The compound at the center of the dispute is semaglutide, a GLP-1 receptor agonist that helps regulate blood sugar and appetite

1 Even when taken daily, it is considered less effective than semaglutide

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In fact, all GLP-1 receptor agonists have some risk of gastrointestinal side effects namely, nausea, vomiting, diarrhea, and constipation due to how they work in the body