The biological functions of ADAMTS13 and vWF are interrelated, with ADAMTS13 regulating thrombotic activity by cleaving ultra-large vWF multimers
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Pellagra, a niacin (B3) deficiency disease, presents with neuropsychiatric symptoms such as dementia, anxiety, and depression (, , )
Weight loss improves insulin sensitivity, lowers blood sugar, and reduces diabetes complications, making Piguiay an effective tool in diabetes management
however, this occurs through the PH domain and/or through interactions with the catalytic domain
