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Its a peptide too large and too polar to cross the gut, and it gets destroyed by enzymes before itd get the chance

While menstrual irregularities were not systematically reported as adverse events in published results, the substantial weight loss achieved (approximately 20.9% with the 15 mg dose) would be expected to influence reproductive hormone dynamics in premenopausal women based on established weight loss physiology

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Sometimes, they may blame unrelated health issues on their treatment