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Semaglutide is highly advisable in cardiovascular diseases (atherosclerotic nature) and in case of intolerance towards SGLT-2 inhibitors

Large outcome trials demonstrated that several GLP-1 agonists significantly reduce major adverse cardiovascular events (heart attack, stroke, cardiovascular death) in patients with type 2 diabetes

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The 15-mg formulation of ertugliflozin is approximately 100% orally bioavailable and has a mean half-life of 16.6 hours